Page 145 - Microsoft Word -Cow Book 10-06-09 final update.doc

generations having increased activity on gram negative bacteria often with
reduced effect on gram + bacteria. Example of its generation is cephapirin,
2nd generation is cefaclor, 3rd generation is cefitraxone, and 4th generation
example is cefpirome.

 Cephapirin
 Ceftiofur sodium
 Ceftiofur hydrochloride

D. Tetracycline

The tetracyclines are typically very broad spectrum drugs. Their spectra
comprise gram-positive and gram-negative bacteria, including some anaer-
obes, Rickettsia, Chlamydia, Mycoplasma, Actinomyces, Spirochetes,
Anaplasma and even some protozoa.

 Tetracycline
 Oxytetracycline
 Chlortetracycline

E. Chloramphenicol

Chloramphenicol is not approved for use in food-producing animals.
The use of chloramphenicol in food-producing animals is a serious
violation of the F,D,&C Act. Chloramphenicol has been demonstrated to
cause fatal a plastic anemia in humans.

F. Florfenicol

Florfenicol was approved in 1996 for use in cattle. It is an effective, broad
spectrum antibiotic active against many gram negative and gram positive
bacteria. Florfenicol is chemically different from chloramphenicol and does
not have the associated human food safety concerns.

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