Page 132 - Microsoft Word -Cow Book 10-06-09 final update.doc

A. NITROFURAN DRUGS: FURAZOLIDONE AND NIROFURAZONE

The withdrawal by FDA of 10 approvals for nitrofuran (furazolidone
and nitrofurazone) on August 23, 1991, affected products that were
approved for a variety of uses in swine and poultry.

Since that time, FDA has taken measures to prohibit the use of all
nitrofuran drugs in food producing animals.

Nitrofuran drugs are listed with those of highest priority for regulato-
ry attention regarding extra-label use in food-producing animals. The
use of furazolidone, nitrofurazone or other nitrofuran in food-producing
animals in any form is no longer allowed.

In addition, Nitrofuran drugs approved as topical nitrofuran drugs are not to
be used or stored on dairy farms. These include salves, ointments, liquid,
and spray or puffer dry powder topicals. (pink eye and wound treatments)

In the past there were two topical nitrofuran products labeled for use in cat-
tle. In 1998 FDA revised the labeling for all topical nitrofurazone and
furazolidone products to remove all claims for use in cattle and other food
animals. There are no longer any nitrofuran drugs approved for use in
cattle. Nirtofuran drugs in any form should not be used to treat dairy cattle
or be stored with the dairy cattle drugs.

 Nitrofuran Solutions, Ointments, Sprays, and Creams:

There are powders, ointments, aerosols (sprays), and creams that contain
furazolidone or nitrofurazone labeled for topical use in horses, dogs, and
cats. These products were not withdrawn by FDA and may be legally
marketed for their intended uses in non-food animals.

The use or storage on dairy farms of any withdrawn nitrofuran drug or the
use of solutions, ointments, sprays and creams labeled as topicals for non-
dairy animals violates item 15r of the PMO.

122